Vitamin D for extremely preterm infants

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Trial of daily vitamin D supplementation in preterm infants.

OBJECTIVE To compare the effect of 800 vs 400 IU of daily oral vitamin D3 on the prevalence of vitamin D deficiency (VDD) at 40 weeks' postmenstrual age (PMA) in preterm infants of 28 to 34 weeks' gestation. METHODS In this randomized double-blind trial, we allocated eligible infants to receive either 800 or 400 IU of vitamin D3 per day (n = 48 in both groups). Primary outcome was VDD (serum ...

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Calcium and vitamin d requirements of enterally fed preterm infants.

Bone health is a critical concern in managing preterm infants. Key nutrients of importance are calcium, vitamin D, and phosphorus. Although human milk is critical for the health of preterm infants, it is low in these nutrients relative to the needs of the infants during growth. Strategies should be in place to fortify human milk for preterm infants with birth weight <1800 to 2000 g and to ensur...

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Extremely preterm infants: poor long-term prognosis

Maternal fever and neural tube defects c Maternal hyperthermia during the first trimester seems to contribute to an increased risk for neural tube defects (NTDs). Animal studies in the 1980s suggested that fever might lead to NTDs; in humans, however, this association was harder to confirm. A case-control study was undertaken to investigate an epidemic of NTDs near the Mexican border in Texas. ...

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Outcome trajectories in extremely preterm infants.

OBJECTIVE Methods are required to predict prognosis with changes in clinical course. Death or neurodevelopmental impairment in extremely premature neonates can be predicted at birth/admission to the ICU by considering gender, antenatal steroids, multiple birth, birth weight, and gestational age. Predictions may be improved by using additional information available later during the clinical cour...

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The management of extremely preterm infants

Extreme prematurity is associated with an increased risk of mortality, morbidities and long-term neurodevelopmental impairment. Optimizing prenatal, perinatal and postnatal care is essential to improve long-term outcome of extremely preterm babies. Intrauterine growth restriction (IUGR) has been associated with a poorer neurological outcome and prenatal care should aim to an optimal balance bet...

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ژورنال

عنوان ژورنال: The Journal of Pediatrics

سال: 2016

ISSN: 0022-3476

DOI: 10.1016/j.jpeds.2016.05.052